Tumors of the Pineal Gland Region

Authors

Sergio H. Susuki, Department of Neurosurgery, Central Nervous System Tumor Reference Center, A.C. Camargo Cancer Center (ACCCC), Sao Paulo, SP, Brazil.
Marcio S. Rassi, Discipline of Neurosurgery, Department of Surgery, Faculty of Medical Sciences of Santa Casa de Sao Paulo, S ˜ ao˜ Paulo, SP, Brazil..I
Jean G. de Oliveira, Department of Neurosurgery, Central Nervous System Tumor Reference Center, A.C. Camargo Cancer Center (ACCCC), Sao Paulo, SP, Brazil.Follow

Document Type

Original Article

Abstract

Pineal gland tumors are a heterogeneous and rare group of neoplasms in adults and children, categorized more by their location than by histological similarities. Their clinical presentation is variable, but due to their anatomical location and function, they frequently present with obstructive hydrocephalus, Parinaud’s syndrome, or neuroendocrine disorders. Surgical resection plays a central role in the treatment of these lesions, complemented by chemotherapy and radiotherapy in some types of tumors, making their histopathological classification fundamental.

Recommended Citation

Susuki, Sergio H.; Rassi, Marcio S.; and de Oliveira, Jean G. (2024) "Tumors of the Pineal Gland Region," LATIN Neurosurgery Journal: Vol. 1: Iss. 2, Article 9.
Available at: https://www.latin-neurosurgery.org/home/vol1/iss2/9

References

[1] S Schipmann, D Keurhorst, M Kochling, ¨ M Schwake, K Heß, B Sundermann, W Stummer, and A Brentrup. Regression of pineal lesions: Spontaneous or iatrogenic? - a case report and systematic literature review. World Neurosurgery, 2017.

[2] MM Shoja, LD Hoepfner, PS Agutter, R Singh, and RS Tubbs. History of the pineal gland. Child’s Nervous System, 2015.

[3] JN Bruce. Pineal tumors. Updated: Aug 27, 2010.

[4] C Carr, BE O’Neill, CB Hochhalter, MJ Strong, and ML Ware. Biomarkers of pineal region tumors: A review. Ochsner Journal, 19:26–31, 2019. © Academic Division of Ochsner Clinic Foundation.

[5] JN Bruce, ES Connolly Jr, and BM Stein. Pineal cell and germ cell tumors. In Andrew H Kaye, editor, Brain Tumors, chapter Part V, Cap 38, pages 725–755. Churchill Livingstone, 1995.

[6] M Posner and G Horrax. Eye signs in pineal tumors. Journal of Neurosurgery, 3:15–24, Jan 1946.

[7] Elizabeth V Hankinson, Christopher J Lyons, Juliette Hukin, and David D Cochrane. Ophthalmological outcomes of patients treated for pineal region tumors. Journal of Neurosurgery: Pediatrics, 17(5):558–563, 2016.

[8] KB Feroze and BC Patel. Parinaud syndrome. StatPearls [Internet], 2019. Bookshelf ID: NBK441892, PMID: 28722922.

[9] M Shields, S Sinkar, WO Chan, and J Crompton. Parinaud syndrome: a 25-year (1991– 2016) review of 40 consecutive adult cases. Acta Ophthalmologica, pages 1–2, 2016.

[10] Monica Fonseca da Costa, Val ˆ eria Santos, ´ Maria Lucia Vellutini Pimentel, and Sergio AP Novis. S´ındrome de parinaud e sinal de collier: manifestac¸ao neurol ˜ ogica inicial em paciente ´ hiv-1 positivo. Arquivos de Neuro-Psiquiatria, 57:876–880, 1999.

[11] Maurizio Iacoangeli, Roberto Colasanti, Domenic Esposito, Alessandro Di Rienzo, Lucia Di Somma, Mauro Dobran, Maurizio Gladi, and Massimo Scerrati. Supraorbital subfrontal trans-laminar endoscope-assisted approach for tumors of the posterior third ventricle. Acta neurochirurgica, 159:645–654, 2017.

[12] X Jiang, Y Chen, Z Zhou, L Luo, W Hu, H Zheng, Z Zhu, J Wang, and Z Chen. Surgical resection of pineal epidermoid cyst contributed to relieving schizophrenia symptoms. World Neurosurgery, 2018.

[13] J Choque-Velasquez, JC Resendiz-Nieves, BR Jahromi, R Colasanti, R Raj, O Tynninen, J Collan, and J Hernesniemi. Pineal parenchymal tumors of intermediate differentiation: A long-term follow-up study in helsinki neurosurgery. World Neurosurgery, 2018.

[14] Y Kinoshita, F Yamasaki, A Tominaga, T Saito, T Sakoguchi, T Takayasu, S Usui, K Sugiyama, K Arita, and K Kurisu. Pitfalls of a neuroendoscopic biopsy of intraventricular germ cell tumors. World Neurosurgery, 2017.

[15] Y Tian, R Liu, J Qin, J Wang, Z Ma, J Gong, and C Li. Retrospective analysis of the clinical characteristics, therapeutic aspects, and prognosis factors of 18 cases of childhood pineoblastoma. World Neurosurgery, 2018.

[16] JH Hara, A Wu, JE Villanueva-Meyer, G Valdes, V Daggubati, S Mueller, TD Solberg, SE Braunstein, O Morin, and DR Raleigh. Clinical applications of quantitative 3-dimensional mri analysis for pediatric embryonal brain tumors. International Journal of Radiation Oncology* Biology* Physics, page 1e13, 2018.

[17] Jens Gempt, Florian Ringel, Karin Oexle, Clemens Delbridge, Anette Forschler, J ¨ urgen ¨ Schlegel, Bernhard Meyer, and Friederike Schmidt-Graf. Familial pineocytoma. Acta Neurochirurgica, 154:1413–1416, 2012.

[18] Francesco Cuccia, Gianluca Mortellaro, Daniela Cespuglio, Vito Valenti, Giorgia De Gregorio, Emanuele Quartuccio, Livio Blasi, Natale Francaviglia, Cristina Gallo, Antonio Lo Casto, et al. A case report of adult pineoblastoma occurring in a pregnant woman. Anticancer Research, 39(5):2627–2631, 2019.

[19] S Magrini, A Feletti, E Marton, and P Longatti. Gliomas of the pineal region. Journal of Neuro-Oncology, 2013.

[20] S Naqvi, C Rupareliya, and A Shams. Pineal gland tumor but not pinealoma: A case report. Cureus, 9:e1576, August 2017.

[21] H Martinez, M Nagurney, Zi-Xuan Wang, CG Eberhart, CM Heaphy, MT Curtis, and FJ Rodriguez. Atrx mutations in pineal parenchymal tumors of intermediate differentiation. Journal of Neuropathology and Experimental Neurology, pages 1–6, 2019.

[22] AM Uppar, H Sugur, AR Prabhuraj, MB Rao, BI Devi, S Sampath, A Arivazhagan, and V Santosh. H3k27m, idh1, and atrx expression in pediatric gbm and their clinical and prognostic significance. Child’s Nervous System, 2019.

[23] Pieter Wesseling and DWHO Capper. Who 2016 classification of gliomas. Neuropathology and applied neurobiology, 44(2):139–150, 2018.

[24] Randy S D’Amico, George Zanazzi, Peter Wu, Peter Canoll, and Jeffrey N Bruce. Pineal region glioblastomas display features of diffuse midline and non-midline gliomas. Journal of neuro-oncology, 140:63–73, 2018.

[25] GBG Andoain, J Delgado-Fernandez, JRP Cuesta, R Gil-Simoes, N Frade-Porto, and MP Sanchez. Meningiomas originated at the falcotentorial region: Analysis of topographic and diagnostic features guiding an optimal surgical planning. World Neurosurgery, 2019.

[26] A Inoue, T Ohnishi, S Kohno, Y Yoshihiro Ohtsuka, Y Nakamura, Y Mizuno, R Kitazawa, and S Ohue. Two cases of pinealregion meningiomas derived from arachnoid membrane over the vein of galen without dural attachment. World Journal of Surgical Oncology, 13:226, 2015.

[27] MV Ortiz and IJ Dunkel. Retinoblastoma. Journal of Child Neurology, pages 1–10, 2010.

[28] MC de Jong, WA Kors, P de Graaf, JA Castelijns, AC Moll, and T Kivela. The in- ¨ cidence of trilateral retinoblastoma: a systematic review and meta-analysis. American Journal of Ophthalmology, 2015.

[29] Saadiah Goolam, Hemant Kana, Nicky Welsh, Linda Wainwright, Janet Poole, and Ismail Mayet. A 20-year retrospective review of retinoblastoma at two tertiary academic hospitals in johannesburg, south africa. Ocular oncology and pathology, 4(3):170–175, 2018.

[30] R Yamanaka, Azusa A Hayano, and Y Takashima. Trilateral retinoblastoma: A systematic review of 211 cases. Neurosurgical Review, 2017.

[31] Luke Galloway and Caroline Hayhurst. Rapid regression of a symptomatic pineal region meningioma after presumed spontaneous central infarction. Acta neurochirurgica, 158:1601–1602, 2016.

[32] SK Belajouza, O Jaidane, M Labidi, C Kraiem, and N Bouaouina. Metastase pin ´ eale d’un car- ´ cinome mammaire: a propos d’un cas et revue ` de la litterature. ´ Publie par Elsevier Masson ´ SAS pour la Societ´ e franc¸aise de radioth ´ erapie ´ oncologique (SFRO), 2014.

[33] Margaret E Flanagan, John R Williams, Samuel N Emerson, Peter A Chiarelli, Richard G Ellenbogen, and Patrick J Cimino. Clinicopathologic characteristics of metastatic esophageal carcinoma isolated to the pineal region: a case report and review of the literature. Experimental and Molecular Pathology, 102(2):247–250, 2017.

[34] Jun J Li, P Wang, and B Wang. Unique case report of pineal gland metastasis from bladder carcinoma. Medicine, 95(18):e3622, 2016.

[35] E Hogan, I Amira-Suarez, S Li, SP Collins, and WC Jean. Clinical management of prostate cancer metastasis to the pineal gland- case report and review of the literature. World Neurosurgery, 2018.

[36] Martin Majovsk ´ y, David Netuka, and Vladim ` ´ır Benes. Conservative and surgical treatment ˇ of patients with pineal cysts: prospective case series of 110 patients. World Neurosurgery, 105:199–205, 2017.

[37] Joham Choque-Velasquez, Roberto Colasanti, Julio Resendiz-Nieves, Behnam Rezai Jahromi, Olli Tynninen, Juhani Collan, Mika Niemela, and Juha Hernesniemi. Papillary tu- ¨ mor of the pineal region in children: presentation of a case and comprehensive literature review. World Neurosurgery, 117:144–152, 2018.

[38] M Fevre Montange and et al. Papillary tumor ` of the pineal region: Histopathological characterization and review of the literature. Neurochirurgie, 2014.

[39] Stephanie Heim, Martin Sill, David TW Jones, Alexandre Vasiljevic, Anne Jouvet, Michelle Fevre-Montange, Pieter Wesseling, ` Rudi Beschorner, Michel Mittelbronn, Patricia Kohlhof, et al. Papillary tumor of the pineal region: a distinct molecular entity. Brain pathology, 26(2):199–205, 2016.

[40] Elzbieta Nowicka, Barbara Bobek-Billewicz, ˙ Janusz Szymas, and Rafał Tarnawski. Late ´ dissemination via cerebrospinal fluid of papillary tumor of the pineal region: a case report and literature review. Folia Neuropathologica, 54(1):72–79, 2016.

[41] Sujata Chaturvedi and Vaishali Suri. Pineal tumors: Rare but challenging entity. Neurology India, 67(2):503–504, 2019.

[42] MA Zaazoue and LC Goumnerova. Pineal region tumors: a simplified management scheme. Child’s Nervous System, 2016.

[43] JG Torres-Corzo, MA Islas-Aguilar, and CD Cerecedo-Lopez. Flexible neuroendoscopic diagnosis and management of ventricular tumors: A retrospective cohort study. World Neurosurgery, pages E1–E6, 2018.

[44] HR Syed and WC Jean. A novel method to measure the “tentorial angle” and the implications on surgeries of the pineal region. World Neurosurgery, 2018.

[45] D Mendez-Rosito. The supra/infra transtentorial transfalcine approach for the removal of a falcotentorial meningioma: 2-dimensional video. Watch at OUP Academic, 2018.

[46] JK Liu. Endoscopic-assisted interhemispheric parieto-occipital transtentorial approach for microsurgical resection of a pineal region tumor: Operative video and technical nuances. Neurosurgical Focus, 40(Suppl1):V13, 2016.

[47] T Bando, Y Ueno, N Shinoda, Y Imai, K Ichikawa, Y Kuramoto, T Kuroyama, M Shimo, K Mikami, S Hori, M Matsumoto, and O Hirai. Therapeutic strategy for pineal parenchymal tumor of intermediate differentiation (pptid): Case report of pptid with malignant transformation to pineocytoma with leptomeningeal dissemination 6 years after surgery. Journal of Neurosurgery, 2018.

[48] David Mathieu and Christian Iorio-Morin. Stereotactic radiosurgery for pineal region tumors. Leksell Radiosurgery, 34:173–183, 2019.

[49] Pier Paolo Mattogno, Paolo Frassanito, Luca Massimi, Gianpiero Tamburrini, Mariangela Novello, Libero Lauriola, and Massimo Caldarelli. Spontaneous regression of pineal lesions: ghost tumor or pineal apoplexy? World Neurosurgery, 88:64–69, 2016.