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LATIN Neurosurgery Journal

Document Type

Original Article

Abstract

Context: Central nervous system tumors in children between 0 and 2 years of age are rare, so their diagnosis and treatment constitute an important challenge for any pediatric neurosurgical center, added, the comorbidities of this age, which condition the responsibility of improving therapeutics to obtain better survival.

Objective: to describe the diagnostic and therapeutic experience of a national reference neurosurgical service, in relation to central nervous system neoplasms in children under two years of age, in addition to establishing comorbidity and prognosis.

Materials and Methods: Cross-sectional, retrospective and descriptive study that includes all patients under 2 years of age who were diagnosed with a neoplastic lesion of the central nervous system, treated from January 1, 2016 to July 1, 2019 at the Hospital Pediatric Baca Ortiz from the city of Quito in Ecuador. Results and

Conclusions: Central nervous system tumors in children between 0 and 2 years of age are not frequent, in this series they corresponded to 5.09%, being the most frequent reason for irritability with 62.5%. 75% of the neoplasms were located at supratentorial level with a 1: 1 intra / extraaxial ratio. Neuroblastoma and choroidal plexus tumors were the most frequent histopathological diagnoses. Mortality had a percentage of 50%.

References

[1] Ana Cristina Toro-Moreno, Laura SernaVelez, Daniel Gallego-Gonzalez, Laura Is- ´ abel Jaramillo-Jaramillo, Lina Mar´ıa Mart´ınezSanchez, and Luis Felipe ´ Alvarez-Hern ´ andez. ´ Tumores de sistema nervioso central en pediatr´ıa: Presente y futuro del abordaje diagnostico. ´ Revista Ecuatoriana de Neurolog´ıa, 26(3):283–288, 2017.

[2] Eric Roddy and Sabine Mueller. Late effects of treatment of pediatric central nervous system tumors. Journal of Child Neurology, pages 1– 19, 2015.

[3] Emily V Walker, Faith G Davis, and CBTR founding affiliates Shaw Amanda Louchini Rabia Shack Lorrains Woods Ryan Kruchko Carol Spinelli John Guiot Marie-Christine Perry James Melin Beatrice Barnholtz-Sloan Jill Turner Donna King MaryJane Hannah Heather Bryant Heather. Malignant primary brain and other central nervous system tumors diagnosed in canada from 2009 to 2013. Neuro-oncology, 21(3):360–369, 2019.

[4] Erin R Bonner, Miriam Bornhorst, Roger J Packer, and Javad Nazarian. Liquid biopsy for pediatric central nervous system tumors. NPJ precision oncology, 2(1):29, 2018.

[5] Chantal Kalifa and Jacques Grill. The therapy of infantile malignant brain tumors: current status? Journal of neuro-oncology, 75:279– 285, 2005.

[6] Patricia A McKinney. Central nervous system tumours in children: epidemiology and risk factors. Bioelectromagnetics, 26(S7):S60–S68, 2005.

[7] Hart Isaacs Jr. Ii. perinatal brain tumors: a review of 250 cases. Pediatric neurology, 27(5):333–342, 2002.

[8] Rebecca L Siegel, Kimberly D Miller, and Ahmedin Jemal. Cancer statistics, 2018. CA: a cancer journal for clinicians, 68(1):7–30, 2018.

[9] Scott L Coven, Joseph R Stanek, Ethan Hollingsworth, and Jonathan L Finlay. Delays in diagnosis for children with newly diagnosed central nervous system tumors. Neurooncology practice, 5(4):227–233, 2018.

[10] C Showers, A Sonabend, and R Anderson. Immunopathology of central nervous system tumors. Immunome Research, 10(1), 2014.

[11] Stephanie Puget, Nathalie Boddaert, Delphine Viguier, Virginie Kieffer, Christine Bulteau, Matthew Garnett, Delphine Callu, Christian Sainte-Rose, Chantal Kalifa, Georges Dellatolas, et al. Injuries to inferior vermis and dentate nuclei predict poor neurological and neuropsychological outcome in children with malignant posterior fossa tumors. Cancer, 115(6):1338– 1347, 2009.

[12] Ricardo Silva Pinho, Solange Andreoni, Nasjla Saba Silva, Andrea Maria Cappellano, Marcelo Rodrigues Masruha, Sergio Caval- ´ heiro, and Luiz Celso Pereira Vilanova. Pediatric central nervous system tumors: a singlecenter experience from 1989 to 2009. Journal of pediatric hematology/oncology, 33(8):605– 609, 2011.

[13] Tryggve Lundar, Bernt Due-Tonnessen, Arild Egge, Bard Krossnes, Einar Stensvold, and Paul Due-Tonnessen. Neurosurgical treatment of brain tumors in the first 6 months of life: Long-term follow-up of a single consecutive institutional series of 30 patients. Childs Nerv Syst, 2015.

[14] A Lacayo and PM Farmer. Brain tumors in children: a review. Annals of Clinical & Laboratory Science, 21(1):26–35, 1991.

[15] Fiona Schulte, Tara M Brinkman, Chenghong Li, Taryn Fay-McClymont, Deo Kumar Srivastava, Kirsten K Ness, Rebecca M Howell, Sabine Mueller, Elizabeth Wells, Douglas Strother, et al. Social adjustment in adolescent survivors of pediatric central nervous system tumors: A report from the c hildhood c ancer s urvivor s tudy. Cancer, 124(17):3596–3608, 2018.

[16] Tonny Solveig Reimers, Susanne Ehrenfels, Erik Lykke Mortensen, Marianne Schmiegelow, Signe Sønderkær, Henrik Carstensen, Kjeld Schmiegelow, and Jørn Muller. Cognitive deficits in long-term ¨ survivors of childhood brain tumors: Identification of predictive factors. Medical and pediatric oncology, 40(1):26–34, 2003.

[17] Mohammad Faranoush, Mohammad TorabiNami, Azim Mehrvar, Amir Abbas HedayatiAsl, Maryam Tashvighi, Reza Ravan Parsa, Mohammad Ali Fazeli, Behdad Sobuti, Narjes Mehrvar, Ali Jafarpour, et al. Classifying pediatric central nervous system tumors through near optimal feature selection and mutual information: A single center cohort. Middle East Journal of Cancer, 4(4):153–162, 2013.

[18] Bruce H Cohen, Roger J Packer, Kathy R Siegel, Lucy B Rorke, Giulio D’Angio, Leslie N Sutton, Derek A Bruce, and Luis Schut. Brain tumors in children under 2 years: treatment, survival and long-term prognosis. Pediatric neurosurgery, 19(4):171–179, 1993.

[19] A. Krivoy, R. Valdivia, J. Molina, and et al. Siwav. Tumores del sistema nervioso central en ninos. ˜ Bol. Ninos JM R ˜ ´ıos, 26:19–24, 1990.

[20] Conti Reed, Sergio Rosemberg, Jose Luiz ´ Dias Gherpelli, Hamilton Matushita, Gilberto G Machado de Almeida, and Aron J Diament. Brain tumors in the first two years of life: a review of forty cases. Pediatric neurosurgery, 19(4):180–185, 1993.

[21] A Krivoy, R Valdivia, J Molina, V Silva, A Gonzalez, M S ´ anchez, E Altuve, W Gordon, ´ and F Cortez. Tumores supratentoriales infan- ´ tiles. Bol. Hosp. Ninos JM de los R ˜ ´ıos, pages 9–15, 1993.

[22] C Jovan´ı Casano, A Canete Nieto, ˜ M Bermudez Cort ´ es, A Verdaguer Mi- ´ ralles, JMF Navvarro, J Ferris Tortajada, and V Castel. Tumores de sistema nervioso central en ninos menores de 3 anos. An Esp Pediatr, 49(2):151–156, 1998.

[23] Pratiti Bandopadhayay, Guillaume Bergthold, Wendy London, Liliana Goumnerova, Andres Morales La Madrid, and Karen Marcus. Longterm outcome of 4,040 children diagnosed with pediatric low-grade gliomas: An analysis of the surveillance epidemiology and end results (seer) database. Pediatr Blood Cancer, 61:1173–1179, 2014.

[24] Jorge Hinojosa, J Esparza, MJ Munoz, and ˜ A Munoz. Tumores cerebrales cong ˜ enitos: pre- ´ sentacion de nueve casos y revisi ´ on de la liter- ´ atura. Neurocirugia, 14(1):33–40, 2003.

[25] F Villarejo and JF Martinez. Tumores cerebrales en ninos. ˜ Pediatr Integral, 16(6):475– 86, 2012.

[26] Tadanori Tomita, David G McLone, Lakshmi Das, and William N Brand. Benign ependymomas of the posterior fossa in childhood. Pediatric Neurosurgery, 14(6):277–285, 1988.

[27] Andrew J Bishop, Mark W McDonald, Andrew L Chang, and Natia Esiashvili. Infant brain tumors: incidence, survival, and the role of radiation based on surveillance, epidemiology, and end results (seer) data. International Journal of Radiation Oncology* Biology* Physics, 82(1):341–347, 2012.

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