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LATIN Neurosurgery Journal

Authors

Eduardo Laos-Plasier, Almenara Hospital, Lima, PeruFollow
Pedro Aleixo-Nogueira, State University of Campinas, Brazil
Armando Alpizar-Aguirre, National Autonomous University of Mexico, Mexico
Tania Arancibia-Baspineiro, Center for Neurological Diseases, Bolivia
Julio C. Burgos-Flores, Central Hospital of the Social Security Institute, Paraguay
Andrei Fernandes-Joaquim, University of Campinas, Brazil
Edson Lizarazu-Oroz, Hospital Obrero Nr 5, Potosı City, Bolivia
Carlos A. Llanos-Lucero, Faculty of Health Sciences. Universidad del Valle, Colombia
José L. López-Segales, Caja Nacional de Salud Hospital Obrero # 3, Bolivia
Thiago Magalhães-de Souza, State University of Campinas, Brazil
Juan F. Mier-García, Faculty of Health Sciences. Universidad del Valle, Colombia
Fernando Molina-Pizarro, Caja Nacional de Salud Hospital Obrero # 3, Bolivia
Filadelfo Normabuena, Hospital Puerto Montt, Chile
María E. Núñez-Castillo, Hospital Central de las Fuerzas Armadas (HCFFAA), Dominican Republic
Erika Reyes-Quezada, Centro CardioNeuro Oftalmologico y Transplante (CECANOT), Dominican Republic
Wilson Quispe-Alanoca, National Institute of Rehabilitation LGII of Mexico City, Mexico
Paulo G. Sacramento-da Silva, State University of Campinas, Brazil
Byron Salazar-Maldonado, Military Hospital, Quito, Ecuador
Jorge Salazar-Flores, Metropolitan Hospital, Quito, Ecuador
Juan C. Salcedo-Moreno, School of Medicine. Faculty of Health Sciences. Universidad del Valle, Colombia
Josselin M. Sánchez-Mamani, Hospital Obrero Nr 5, Potosí city, Bolivia
Felipe A. Santos-de Queiroz-Chaves, Neurosurgery Resident, State University of Campinas, Brazil
Reddy A. Simón-Nunes, Central Hospital of the Social Security Institute, Paraguay
Manuel E. Soto-García, Minimally Invasive Spine Surgery, Neurological Center, The American-British Cowdray Medical Center IAP, Mexico
Perla M. Del Valle-Oros, Universidad de Sonora, Mexico
José A. Israel-Romero-Rangel, The American-British Cowdray Medical Center IAP, Campus Santa Fe, CDMX, Mexico
Luis M. Duchén-Rodríguez, Center for Neurological Diseases, Public University of El Alto, Bolivia
José A. Soriano-Sánchez, The American British Cowdray Medical Center IAP, Mexico

Document Type

Original Article

Abstract

Introduction: Interferon-gamma release assays are indirect immunological tests used mainly for the diagnosis of latent tubercu losis, their use in active tuberculosis being controversial. This study aims to analyze the usefulness of gamma interferon release assays in the diagnosis of spinal tuberculosis and to obtain a consensus for their use.
Methods: A systematized search was carried out in PubMed and Scielo for ar ticles in English, Spanish, or Portuguese from 10/01/2012 to 10/01/2022, eligibility criteria were applied, the papers included were analyzed according to the GRADE methodology and then established the SORT type recommendation.
Results: We obtained 27 articles, of which only five we considered suitable for analysis; 4 were of low quality and one very low quality. The interferon-gamma release assays used were T.SPOT-TB and QuantiferonTB Gold in tube, both of which showed high sensitivity and moderate to high specificity for QuantiferonTB Gold in tube and T.SPOT-TB, respectively.
Discussion/Conclusion: Despite the low quality of the articles, we consider a type B recommendation (SORT) for the use of IGRA (T.SPOT-TB and QuantiferonTB Gold in tube) as a complementary test in the diagnosis of spinal tuberculosis, in the absence of definitive test results with high clinical imaging suspicion.

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