LATIN Neurosurgery Journal


Armando Alpizar-Aguirre, National Autonomous University of Mexico, MexicoFollow
Pedro Aleixo-Nogueira, University of Campinas, Brazil
Tania Arancibia-Baspineiro, State University of Campinas, Brazil
Julio C. Burgos-Flores, Central Hospital of the Social Security Institute, Paraguay
Andrei Fernandes Joaquim, University of Campinas, Brazil
Eduardo Laos-Plasier, Almenara Hospital, Lima, Peru
Edson Lizarazu-Oroz, Hospital Obrero Nr 5, Potosı City, Bolivia
Carlos A. Llanos-Lucero, Faculty of Health Sciences. Universidad del Valle, Colombia
Jose L. López-Segales, Caja Nacional de Salud Hospital Obrero # 3, Bolivia
Thiago Magalhães-de Souza, State University of Campinas, Brazil
Juan F. Mier-Gracía, Faculty of Health Sciences. Universidad del Valle, Colombia
Fernando Molina-Pizarro, Caja Nacional de Salud Hospital Obrero # 3, Bolivia
Filadelfo Normabuena, Hospital Puerto Montt, Chile
María E. Núñez-Castillo, Hospital Central de las Fuerzas Armadas (HCFFAA), Dominican Republic
Erika Reyes-Quezada, Centro CardioNeuro Oftalmologico y Transplante (CECANOT), Dominican Republic
Wilson Quispe-Alanoca, National Institute of Rehabilitation LGII of Mexico City, Mexico
Paulo G. Sacramento-da Silva, State University of Campinas, Brazil
Juan C. Salcedo-Moreno, School of Medicine. Faculty of Health Sciences. Universidad del Valle, Colombia
Josselin M. Sánchez-Mamani, Hospital Obrero Nr 5, Potosı City, Bolivia
Felipe A. Santos-de Queiroz-Chaves, Neurosurgery Resident, State University of Campinas, Brazil
Byron Salazar-Maldonado, Military Hospital Quito, Quito, Ecuador
Jorge Salazar-Flores, Metropolitan Hospital, Quito, Ecuador
Reddy A. Simón-Nunes, Central Hospital of the Social Security Institute, Paraguay
Manuel E. Soto-García, Minimally Invasive Spine Surgery, Neurological Center, The American-British Cowdray Medical Center IAP, Mexico
Perla M. Del Valle-Oros, Universidad de Sonora, Mexico
José A. Israel-Romero-Rangel, The American-British Cowdray Medical Center IAP, Campus Santa Fe, CDMX, Mexico
Luis M. Duchén-Rodríguez, Center for Neurological Diseases, Public University of El Alto, Bolivia
José A. Soriano-Sánchez, The American British Cowdray Medical Center IAP, Mexico

Document Type

Original Article


Introduction: Vertebral biopsy, espe cially percutaneous biopsy for histopathologi cal study and culture, continues to be the Gold Standard in the Diagnosis of Spinal Tubercu losis since the last century, however, there are no recent systematic reviews of the literature on its effectiveness in this pathology.
Method: A systematic review was car ried out on the PubMed platform, with the keywords ”Spinal tuberculosis” and ”Biopsy” in the title and abstract with a time limitation from January 1, 2017 to October 26, 2022. A summary of 11 selected articles was prepared, a list of the variables used in each article was made and special interest was placed on the effectiveness reported in the biopsy.
Results: 43 articles were found, of which 32 wereeliminated because they were consid ered to have little scientific evidence, review ing the remaining 11. A summary was made, the variables used were listed and, above all, the efficacy reported in the use of vertebral biopsy in the Diagnosis of Spinal Tuberculo sis.
Conclusions: In the articles reviewed, an effectiveness was obtained in the biopsy rang ing from 44.68 to 58% and in the case of Gen Xpert/MTB from 65 to 77.78%, so we con sider that this is still low and in some cases it is due to initiate medical treatment taking into account only the clinical picture and the result of the rest of the studies carried out.


[1] Antonio Rivas Garc´ ıa. Biopsia ver tebral percut´anea (BVP): an´alisis de resultados. Universitat Aut` onoma de Barcelona,, 2005.
[2] Harry N. Herkowitz, Steven R. Garfin, Frank J. Eismont, Glenn R. Bell, and Richard A. Balderston. Rothman Simeone The Spine: Expert Consult: Online, Print and DVD, 2-Volume Set. W. B. Saunders, London, England, 6th edition, 2011.
[3] Mayukh Guha, Hitesh Lal, Tankeswar Boruah, Sapan Kumar, Atul Sareen, Mohit Kumar Patralekh, Ramesh Ku mar, and Geetika Khanna. Clinico radio-histopathological correlation by c arm image-guided biopsy in spinal tu berculosis. Indian Journal of Or thopaedics, 55:1028–1036, 2021.
[4] Vijay Karthek, Pramod Bhilare, Shailesh Hadgaonkar, Ajay Kothari, Ashok Shyam, Parag Sancheti, and Siddharth N Aiyer. Gene xpert/mtb rif assay for spinal tuberculosis-sensitivity, specificity and clinical utility. Journal of Clinical Orthopaedics and Trauma, 16:233–238, 2021.
[5] Madan Mohan Sahoo, Sudhir Kumar Mahapatra, Gopal Chandra Sethi, An shuman Sahoo, and Bikram Keshari Kar. Role of percutaneous transpedicu lar biopsy in diagnosis of spinal tubercu losis and its correlation with the clinico radiological features. Indian Journal of Tuberculosis, 66(3):388–393, 2019.
[6] Anil M Solanki, Saumyajit Basu, Ami tava Biswas, Subhendu Roy, and Aditya Banta. Sensitivity and specificity of gene xpert in the diagnosis of spinal tuberculosis: a prospective controlled clinical study. Global Spine Journal, 10(5):553–558, 2020.
[7] OSaidane, M Sellami, S Cheikhrouhou, I Mahmoud, ABEN TEKAYA, R Tekaya, and L Abdelmoula. Profil clinique et facteurs pronostiques du mal de pott au nord de la tunisie: `a propos de 60 cas. Bull. Soc. Pathol. Exot, 112:71–78, 2019.
[8] Yang-Hui Jin, Shi-Yuan Shi, Qi Zheng, Jian Shen, Xiao-Zhang Ying, and Yi Fan Wang. Application value of xpert mtb/rif in diagnosis of spinal tubercu losis and detection of rifampin resis tance. Zhongguo gu Shang= China Journal of Orthopaedics and Trauma tology, 30(9):787–791, 2017.
[9] Armando Luis Miguel Guadalupe Bar´ on Zarate Alpizar Rosales S´ anchez Kalfopulos, Aguirre, Olivares, Bringas, Josue Giovanni Escutia Garc´ ıa, and Alejan dro Reyes S´anchez. Evaluaci´ on de una nueva sistematizaci´ on de estudios para el diagn´ ostico del s´ ındrome de de strucci´ on vertebral. Coluna/Columna, 11:151–155, 2012.
[10] Armando Alpizar-Aguirre, Alejandro Elias-Escobedo, Luis Miguel Rosales Olivares, V´ ıctor Miramontes-Martinez, and Alejandro Reyes-S´ anchez. Cir cir. Cir Cir, 76(3):205–211, May-Jun 2008.
[11] Ebell Mh. Strength of recommendation taxonomy (sort): a patients-centered ap proach to grading evidence in the med ical literature. Am Fam Physician, 69:548–556, 2004.
[12] Bhavuk Garg, Nishank Mehta, Rudra Narayan Mukherjee, Arun M Swamy, Burhan S Siamwala, and Garima Malik. Epidemiological in sights from 1,652 patients with spinal tuberculosis managed at a single center: A retrospective review of 5-year data. Asian Spine Journal, 16(2):162–172, 2022.
[13] Gang Zu, Jun Fei, Genjun Chen, Jitang Yang, et al. C-arm fluoroscopy-guided percutaneous needle biopsy for the di agnosis of spinal infection: A study of 203 consecutive patients. Evidence Based Complementary and Alternative Medicine, 2022:4155113, 2022.
[14] Jung Ho Kim, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Young Keun Kim, Joon-Sup Yeom, and Young Goo Song. Prognostic factors for unfavourable outcomes of patients with spinal tuberculosis in a country with an intermediate tuberculosis bur den: a multicentre cohort study. The bone & joint journal, 101(12):1542 1549, 2019.
[15] Janardhana P Aithala, Arshad Attar, Ahammed KA Imthiaz, and Mahabala Rai. Is there a change in trend to wards pyogenous spondylodiscitis com pared to tubercular spondylodiscitis in india–a study of percutaneous biopsy evaluation in spondylodiscitis. Indian Journal of Tuberculosis, 67(4):509–514, 2020.
[16] Gokul Kafle, Bhavuk Garg, Nishank Mehta, Raju Sharma, Urvashi Singh, Devasenathipathy Kandasamy, Prasenjit Das, and Buddhadev Chowdhury. Di agnostic yield of image-guided biopsy in patients with suspected infectious spondylodiscitis: a prospective study from a tuberculosis-endemic country. The Bone & Joint Journal, 104(1):120 126, 2022.